If the percentage of creatinine that is secreted is ignored, then all of the filtered creatinine equal to the product of the GFR and the serum creatinine concentration [SCr] will be excreted equal to product of the urine creatinine concentration [UCr] and the urine flow rate or volume [V]. This formula is called the creatinine clearance and tends to exceed the true GFR by 10 to 20 percent or more depending upon the proportion of urinary creatinine that is derived from tubular secretion.
For more, see this article. Formulas like the Cockcroft-Gault Equation allow us to estimate GFR without using a hour urine collection by just using their sex, weight, age, and serum creatinine.
US units. Press 'Calculate' to view calculation results. Load an Example. Prediction of creatinine clearance from serum creatinine. PMID A new equation to estimate glomerular filtration rate. Ann Intern Med. Jelliffe RW. Letter: Creatinine clearance: bedside estimate. Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat-free body mass.
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Ann Pharmacother. Estimation of creatinine clearance in morbidly obese patients. Am J Health Syst Pharm. Experience with a once-daily aminoglycoside program administered to 2, adult patients. Antimicrob Agents Chemother. Devine BJ. Serum creatinine is a relatively insensitive indicator of renal disease. A change in serum creatinine from 0. If a previous baseline creatinine is not available for comparison, a serum creatinine level of 1.
Calculation of CCr requires collection of a hour urine and a blood sample during the same interval. Twenty four-hour urine collections are considered optimal because they account for diurnal variation in creatinine clearance.
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